Dose Calculations

Infusion of 10 gm/day of NXY-059 1% "contaminated" by (say) NtBHA would mean a patient also receiving 100 mg. To be conservative, round this off to 70 mg, i.e. 1 mg/kg/day, about.

5 mg/kg/day of NtBHA produces significance radiation protection in mice (Lee, et al). Assuming the usual rodent-human dose conversion factor of about 7-10 fold, this converts to a human equivalent dose of 0.5-0.7 mg/kg/day, within the range arguably received in the SAINT-1 trial.